GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs7246967 | 1 | rs8113312 | chr19:23061182 | ZNF492 | chr19:22817126-22850472:+ | -0.52 | -5.7 | 1.32E-7 | Bronchopulmonary dysplasia |
| THYM | cis | rs703842 | 1 | rs8181644 | chr12:58173466 | FAM119B | chr12:58166383-58176323:+ | 0.42 | 5.82 | 7.89E-8 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs8181644 | chr12:58173466 | TSFM | chr12:58176536-58191367:+ | -0.26 | -4.49 | 1.97E-5 | Multiple sclerosis |
| THYM | cis | rs10461617 | 1 | rs832551 | chr5:56180112 | C5orf35 | chr5:56205103-56213010:+ | 0.75 | 9.04 | 1.84E-14 | Type 2 diabetes |
| THYM | cis | rs10461617 | 1 | rs832553 | chr5:56114786 | C5orf35 | chr5:56205103-56213010:+ | 0.75 | 9.44 | 2.59E-15 | Type 2 diabetes |
| THYM | cis | rs10461617 | 1 | rs832554 | chr5:56115036 | C5orf35 | chr5:56205103-56213010:+ | 0.75 | 9.44 | 2.59E-15 | Type 2 diabetes |
| THYM | cis | rs10461617 | 1 | rs832565 | chr5:56150803 | C5orf35 | chr5:56205103-56213010:+ | 0.75 | 9.04 | 1.84E-14 | Type 2 diabetes |
| THYM | cis | rs10461617 | 1 | rs832568 | chr5:56153776 | C5orf35 | chr5:56205103-56213010:+ | 0.75 | 9.04 | 1.84E-14 | Type 2 diabetes |
| THYM | cis | rs10461617 | 1 | rs832569 | chr5:56154584 | C5orf35 | chr5:56205103-56213010:+ | 0.75 | 9.04 | 1.84E-14 | Type 2 diabetes |
| THYM | cis | rs10461617 | 1 | rs832578 | chr5:56164223 | C5orf35 | chr5:56205103-56213010:+ | 0.77 | 9.59 | 1.25E-15 | Type 2 diabetes |
| THYM | cis | rs10461617 | 1 | rs832582 | chr5:56177743 | C5orf35 | chr5:56205103-56213010:+ | 0.75 | 9.04 | 1.84E-14 | Type 2 diabetes |
| THYM | cis | rs10461617 | 1 | rs832583 | chr5:56178217 | C5orf35 | chr5:56205103-56213010:+ | 0.75 | 9.04 | 1.84E-14 | Type 2 diabetes |
| THYM | cis | rs10461617 | 1 | rs832584 | chr5:56179212 | C5orf35 | chr5:56205103-56213010:+ | -0.75 | -9.04 | 1.84E-14 | Type 2 diabetes |
| THYM | cis | rs844917 | 1 | rs844917 | chr20:23141655 | CD93 | chr20:23059994-23066977:- | 0.4 | 4.14 | 7.5E-5 | Liver enzyme levels (alanine transaminase) |
| THYM | cis | rs854572 | 1 | rs854572 | chr7:94954696 | PON1 | chr7:94927671-95025687:- | 0.41 | 6.03 | 3.14E-8 | Paraoxonase activity |